BAT Study: Unheated Cigarettes Reduce Health Risks in Smokers | Local


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Summary of a year-long research study of 267 people in the UK for British American Tobacco Plc. A significant risk-reducing role was found for non-heat-burning traditional cigarette glo compared to traditional cigarettes.

The final report was published last week in the Journal of Internal and Emergency Medicine. The first six-month report was released on July 1.

The Glo product has not been approved by the Food and Drug Administration.

It is the latest in a series of reports on smoke-free tobacco and nicotine products published by an Italian research group.

“The overall results show that smokers who switched to GLO alone … achieved significant and sustained improvements in several indicators of risk factors associated with early disease development compared to smokers who continued to smoke,” the study authors said.

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This includes lung disease, cancer and cardiovascular disease.

The publication notes that the four principal researchers are employees of BAT or RJ Reynolds Tobacco Company, and that BAT holds the intellectual property rights to the research. The report notes that Glo is not risk-free and can be addictive.

Reynolds American Inc., BAT’s largest global subsidiary, has about 2,500 employees at its U.S. headquarters in Forsyth County.

Researchers evaluated traditional and heat-less cigarette smokers for 12 months. The smokers were between the ages of 23 and 55 and were in good general health. Some wanted to stop but others didn’t.

Researchers concluded that the individual health benefits of glo smokers increase with “the weight of evidence that glo is a very risky option for adolescent smokers to quit.”

David O’Reilly, director of scientific research at BAT, said the study “allows us to assess the changes that adult smokers experience only when they switch to GLO, assessing early indicators of potential harm associated with disease progression.”

“It provides important new information about the rate of change and the sustainability of the impact of a full switch to GLO, and strengthens GLO’s ability to mitigate risk production.”

Research findings

Smokers who did not intend to quit were randomized to either continue smoking or to use GLON alone.

Smokers who expressed a desire to quit were offered access to nicotine replacement therapy and cessation counseling.

Meanwhile, a never-smoking group was included as a control group. Continue not to use tobacco or nicotine products.

Participants were required to attend monthly clinic visits where blood, urine and other parameters were taken. These samples were tested for “Biomarkers of Exposure” (for selected cigarette smoke toxins) and “Biomarkers of Vulnerability”.

Preliminary research findings

  • A significant and sustained reduction in biomarkers of DNA damage associated with lung cancer;
  • A significant and persistent reduction in white blood cells, a sign of inflammation associated with the early development of cardiovascular disease and other smoking-related diseases;
  • Continuous improvement in HDL cholesterol associated with the development of cardiovascular diseases;
  • Significant and sustained improvement in lung health indicators; And
  • A significant and sustained improvement in oxidative stress, a key indicator implicated in many smoking-related diseases such as cardiovascular disease.

“Our findings support the idea that the harmful (harmful or harmful) health effects of cigarette smoking can be reduced in smokers who switch completely to tobacco products,” the report said.

“For most of the biomarkers measured, the reductions seen in people using GLON were similar to those in participants who stopped smoking completely.”


While BAT emphasizes increasing compliance with public-health goals to reduce US and international traditional cigarette consumption, it continues to face deep skepticism from anti-tobacco and public health advocates.

Most anti-tobacco advocacy groups examine smoke-free innovations to see if they can serve a public-health benefit — or whether they work for tobacco-advance products, especially for youth.

In January 2020, then-US Surgeon General Dr. Jerome Adams released a 30-year update on smoking-cessation efforts that sent a mixed message about the effectiveness of e-cigarettes.

E-cigarettes are not currently approved by the Food and Drug Administration as a smoking aid, and are not considered safe products for any user.

“E-cigarettes, an ever-changing and diverse product group, are used in a variety of ways,” Adams said in the 20-page consumer guide.

“Therefore, it is difficult to make generalizations about the effectiveness of quitting based on clinical trials involving a particular e-cigarette. More research is needed on the effectiveness of e-cigarettes in smoking cessation and to better understand the health risks of e-cigarettes.

Adams also said there is a need to “meet smokers where they are.”

The cumulative nature of the BAT report shows that the number of people who believe smoking is as harmful or more harmful than regular smoking has increased in the UK, Europe and the US over the past decade.

Although many scientific reviews have been published at the same time, they show that products produced according to quality standards have less risk to health than cigarettes.

“The scientific evidence is clear – but consumer misconceptions remain,” BAT said.

Market presence

Glo is primarily available in Japan, where it had a 6.2% market share among all nicotine products as of July.

Analysts say BAT, which has garnered the lion’s share of attention and public health criticism of Philip Morris International, is playing catch-up on its pledge to phase out cigarette sales.

For example, in June 2020, the FDA approved the company’s global heat-resistant traditional cigarettes to be marketed as improved risk-free tobacco products.

The heat-resistant product was sold internationally as IQOS, but in the United States it was sold as Marlboro Heatsticks.

However, in November, the US Trade Representative secured a significant legal victory for Batt, involving a patent infringement lawsuit against rival Philip Morris International.

On September 29, 2021, the US International Trade Commission He made the final decision The Tariff Act of 1930 by Philip Morris USA Inc. and Altria Client Services LLC regarding infringement of two BAT product patents.

Due to the ITC decision, PM USA is prohibited from importing PMI IQOS 2.4, IQOS 3, IQOS 3 Duo heat resistant cigarette products.

Also, sales of Marlboro Hatsticks, which include convenience stores in the Triads and North Carolina, were ordered to cease going forward.

Altria appealed to the federal court of appeals, which hears patent lawsuits. A hearing was held in June in which ITC lawyers recommended the appeals court uphold the agency’s decision.

That appeals process can take up to a year to reach a decision, making the chances of a successful appeal slim, industry analysts say.


The Glo study comes at an early stage in BAT’s transition from traditional cigarettes to low-risk tobacco and nicotine products.

BAT said its next-generation products reached 19.4 million users globally in June, up from 18.3 million as of December 31.

For fiscal 2021, new category revenue with a heavy Reynolds impact was $2.79 billion, up 51.8% from fiscal 2020.

New category products are led by RJ Reynolds Vapor Co.’s Vuse – America’s top-selling electronic cigarette, along with Glo and modern oral products led by top-selling Camel Snus and Velo.

The Vuse’s market share increased from 37.4% to 39% in the previous report, while the Joule fell from 30.7% to 29.4%. The latest Nielsen convenience store data analysis represents the four-week period ending August 13.

According to Barclays, Nielsen covers mostly large chains. For the smaller chains, the group avoids trends, which is why trend changes are not immediately visible in Nielsen.

In recent months, the specter of Joule Labs Inc’s possible ban of e-cigarettes from US retail shelves has boosted Vuse’s market share.

In May, BAT unveiled the Vuse Go dropshipping style in the UK, with additional market releases planned for the second half of 2022.

BT chief executive Jack Bowles expressed confidence in June that BAT would achieve its target of at least $6.79 billion in annual new category revenue by 2025.

The manufacturer said it has spent about $1.25 billion on the development of the next-generation product in the first half of 2022.

A BAT-compiled report released in June summarizes the findings of nearly 10 years of scientific research on smoke-free products. Some studies have reduced the risk of exposure to electronic cigarettes, while others have warned that such products are no safer than traditional cigarettes.

“This paper is a comprehensive summary of more than 300 peer-reviewed scientific papers and other data published by approximately 50 institutions over the past decade,” O’Reilly said in June.

“We hope this paper will be used as a resource by public health authorities and those seeking to understand the breadth of scientific evidence available to inform adult smokers of their choices.

In July, BAT unveiled its latest attempt to close the innovation gap in the heat-resistant category with a version of the Glo brand hyper X2 in Tokyo. Not available in America

How the Glo hyper X2 performs will be crucial for BAT, given that Japan is the world’s leading market, representing 85 percent of heat-burnt traditional cigarette sales.

The Hyper X2 Edition “offers advanced induction heating technology in a small and lightweight device … with a special boost function for faster heating,” the company said.

Kingsley Wheaton, chief marketing officer of BAT, said the Hyper X2 is “another key milestone in our evolution as we build our future brands.”

Since launching our first Glo product in Japan in 2016, we have built Glo into a billion dollar global brand through deep consumer insights, science and innovation.

There are plans to roll out hyper X2 in 24 other global markets where Glo products are sold.


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